Cell based assays

The cell culture labo­ra­tory of VelaLabs supports Pharma and Biotech compa­nies with customized cell based assays to deter­mine bioac­tivity and prop­er­ties of biophar­ma­ceu­ti­cals, ther­a­peutic proteins, vaccines, etc..

Analyt­ical methods are set up and devel­oped according to analyt­ical quality by design (QbD). Method qual­i­fi­ca­tion and vali­da­tion is performed in accor­dance with the applic­able guide­lines, e.g. ICH Q2R2 and USP1032 to 1034.

Potency / Biolog­ical Activity Assays

  • Cyto­tox­i­city Assays (e.g. ADCC, CDC)
  • Apop­tosis Assays (e.g. Caspase 3/7)
  • Prolif­er­a­tion / Anti-Prolif­er­a­tion / Inhi­bi­tion Assays
  • Cell signaling / Cellular response Assays (e.g. cAMP)
  • Binding / Flow Cytom­etry Assays
  • Cell acti­va­tion assays
  • Reporter Gene Assays
  • Customized assays

Virus Titer Assays

  • Virus
  • Virus-like parti­cles

Special­ized Assays, tailor­made devel­oped for the mole­cule of interest

  • Whole blood assays
  • PBMC isola­tion

Cell Char­ac­ter­i­za­tion and Main­te­nance under BSL1 and BSL2

  • Gener­a­tion of master (MCB) cell bank and working cell bank (WCB)
  • Cell char­ac­ter­i­za­tion (e.g. growth char­ac­ter­is­tics, gener­a­tion of
    stan­dard culti­va­tion procedure)
  • Receptor Expres­sion
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