Cellbased assays

The cell culture labo­ra­tory of VelaLabs supports Pharma and Biotech compa­nies with customized cell based assays to deter­mine bioac­tivity and prop­er­ties of biophar­ma­ceu­ti­cals, ther­a­peutic proteins, vaccines, etc..

Analyt­ical methods are set up and devel­oped according to analyt­ical quality by design (QbD). Method qual­i­fi­ca­tion and vali­da­tion is performed in accor­dance with the applic­able guide­lines, e.g. ICH Q2R2 and USP1032 to 1034.

Potency / Biolog­ical Activity Assays

• Cyto­tox­i­city Assays (e.g. ADCC, CDC)
• Apop­tosis Assays (e.g. Caspase 3/7)
• Prolif­er­a­tion / Anti-Prolif­er­a­tion / Inhi­bi­tion Assays
• Cell signaling / Cellular response Assays (e.g. cAMP)
• Binding / Flow Cytom­etry Assays
• Cell acti­va­tion assays
• Reporter Gene Assays
• Customized assays

Virus Titer Assays

• Virus
• Virus-like parti­cles

Special­ized Assays, tailor­made devel­oped for the mole­cule of interest

• Whole blood assays
• PBMC isola­tion

Cell Char­ac­ter­i­za­tion and Main­te­nance under BSL1 and BSL2

• Gener­a­tion of master (MCB) cell bank and working cell bank (WCB)
• Cell char­ac­ter­i­za­tion (e.g. growth char­ac­ter­is­tics, gener­a­tion of
  stan­dard culti­va­tion procedure)
• Receptor Expres­sion